As many as fifty thousand Jews from the lands of the former Ottoman Empire came to the United States in the decades surrounding World War I. They constituted a tiny minority within the broader Jewish American community. How did the newly arriving Sephardic Jews adapt to their new country of residence? What became of their language, culture, religious traditions, and connections to their places birth? How was their experience shaped by interactions with their new neighbors, including Yiddish-speaking Jews? This lecture will explore the trajectories of Sephardic Jews from the Mediterranean world to America during the twentieth century.